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Christina Applegate's Multiple Sclerosis Battle: Lesions on Her Brain, Isolating and Living 'in Hell'

Of the disease, Christina Applegate candidly said, "I'm never gonna wake up and go, 'This is awesome.'"

In August 2021 at the age of 49, Applegate announced she had been diagnosed with multiple sclerosis -- commonly referred to as MS-- a "potentially disabling disease of the brain and spinal cord (central nervous system)," according to the Mayo Clinic. The star credits fellow actress and Sweetest Thing co-star Selma Blair, who announced her own MS diagnosis in 2018, with ultimately getting tested. Following the postponement of the 2023 Emmys to January 2024, Applegate received the warmest of welcomes when she stepped out onto the stage as the first presenter that night, accompanied by host Anthony Anderson, to a standing ovation.

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