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Christina Applegate's Multiple Sclerosis Battle: What She's Said About Living With 'Excruciating' Pain


Of the disease, Christina Applegate candidly said, "I'm never gonna wake up and go, 'This is awesome.'"

In August 2021 at the age of 49, Applegate announced she had been diagnosed with multiple sclerosis -- commonly referred to as MS-- a "potentially disabling disease of the brain and spinal cord (central nervous system)," according to the Mayo Clinic. It is with that signature blend of boldness, transparency and humor that Applegate, also a breast cancer survivor, has invited fans to understand more about what her life with MS has been like ever since. Following the postponement of the 2023 Emmys to January 2024, Applegate received the warmest of welcomes when she stepped out onto the stage as the first presenter that night, accompanied by host Anthony Anderson, to a standing ovation.

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