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Christina Applegate Jokes She Looks Like ‘Humpty Dumpty’ with ‘No Muscles’ in Legs

Christina Applegate was diagnosed with multiple sclerosis in 2021.

During an episode of the “MeSsy” podcast on Tuesday, August 20, which she co-hosts with actor Jamie-Lynn Sigler, Applegate used a specific children’s book character to describe how her body has changed. MS is a disease in which the body’s immune system attacks the brain and spinal cord, leading to symptoms such as muscle stiffness and difficulties with walking and talking. The Anchorman, Married With Children, and Bad Moms star previously discussed her insecurities about aging and her appearance during an August 1 episode of the podcast.

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