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Christina Applegate details painful experience living with MS: 'I lay in bed screaming'

Christina Applegate is opening up about the painful symptoms that she experiences living with multiple sclerosis (MS): 'I lay in bed screaming.'

The Mayo Clinic defines multiple sclerosis (MS) as a disease that occurs when the "immune system attacks the protective sheath that covers nerve fibers, known as myelin." Applegate's symptoms came up on the podcast as part of her and Sigler's conversation with guest Rory Kandel, a California bakery owner who has also been diagnosed with MS. The Rory's Bakehouse founder noted that her own symptoms often "manifest in pain" that feels like having "knives in your spine" that prevent her from moving at times.

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